Cardiomyopathy

The cardiomyopathies are a relatively common group of serious diseases characterized by damage to the heart muscle. They form the most frequent indication for cardiac transplantation. There are three main types: hypertrophic (HCM), dilated (DCM) and restrictive cardiomyopathies. Duchenne and Becker muscular dystrophies often produce some very similar cardiac symptoms.

Dilated Cardiomyopathy: Dilated Cardiomyopathy is a biochemical abnormality of cardiac muscle in which the heart chambers become grossly enlarged, with a greatly reduced contractility.

Hypertrophic Cardiomyopathies: Hypertrophic Cardiomyopathies are a group of familial Disorders.

  • Type 1: cardiac myosin heavy chain-causes sudden death young athletes
  • Type 2: Cardiac troponin T2
  • Type 3:Alpha tropomyosin
  • Type 4:Cardiac myosin-binding protein
  • Type 5:Unknown Cause 

Restrictive Cardiomyopathy:  Restrictive Cardiomyopathy is associated with poor cardiac filling caused by scarring of the endocardium, or by infiltration of the cardiac muscle by amyloid deposits.

Duchenne Muscular dystrophy:  Duchenne muscular dystrophy the milder Becker variant are both associated with a late onset of cardiomyopathy. X-linked cardiomyopathy may develop in a few cases without skeletal muscle involvement where the genetic damage is confined to the cardiac-specific dystrophin promoter. 

Market Report:

163 occurrence of pheochromocytoma and cardiomyopathy. Many patients lacked classic signs or symptoms of pheochromocytoma with only 4%. Resection of the pheochromocytoma led to the improvement of the cardiomyopathy in 96% while lack of resection was associated with death or cardiac transplantation in 44%.

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Abstract Deadline
31/01/2021